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Because nocardia infections are most likely to affect the lungs, brain, and skin, the diagnosis should be suspected in individuals who have symptoms characteristic of this disorder in any of those organs, particularly if they have immune disorders.
Nocardiosis is definitively diagnosed by identification of the bacteria in culture. Depending on the site involved this may involve obtaining a tissue sample for staining and culture by way of the following:
- sputum culture
- bronchoscopy
- lung biopsy
- skin biopsy
- brain biopsy
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