Syphilis - secondary

Injury	Disease	Nutrition	Poison

Symptoms	Surgery	Test	Special Topic

Syphilis, secondary on the palms

Overview

Symptoms

Treatment

Prevention

Syphilis - secondary

Alternative Names:

Secondary syphilis

Symptoms:

skin rash - usually throughout the body with both flat and raised patches which may involve the palms and soles
enlarged lymph nodes
mucous patches (painless silvery ulcerations of mucous membranes -- seen mostly in the mouth and on the genitals)
condyloma lata: coalescing papules which form a grey-white plaque frequently in folds such as groin, genital areas, axilla and under the breasts
hair loss (alopecia)
general symptoms such as fever, fatigue, loss of appetite, aches and pains in bones, achy muscles, and achy joints
in a few cases of secondary syphilis, the original chancre may still be present

Signs and tests:

The diagnosis of secondary syphilis is usually based on blood tests. An initial screening is done with the non-treponemal tests such as VDRL or RPR. If these are positive, the diagnosis is confirmed by another blood test for a specific antibody - the FTA-ABS fluorescent treponemal antibody test.

In addition to blood tests, if skin or mucous membrane lesions are present, the organism which causes syphilis may be identified on darkfield microscopic examination.

Review Date: 6/15/2005
Reviewed By: Monica Gandhi, M.D., M.P.H., Assistant Professor, Division of Infectious Diseases, UCSF, San Francisco, CA. Review provided by VeriMed Healthcare Network.

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