A chalazion develops within the Meibomian glands of the eyelid, which are sebaceous glands that produce the tear film that lubricates the eyes. The eyelid has approximately 100 of these glands, located near the eyelashes. The condition is caused by obstruction of the duct that drains one of these glands. A chalazion begins as diffuse swelling and tenderness, and later forms a cyst-like localized swelling. Many chalazia disappear without treatment after a few months.
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