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Mastoiditis may be difficult to treat because it is difficult for medications to reach deep enough into the mastoid bone. It may require repeated or long-term treatment. Antibiotics by injection, then antibiotics by mouth are given to treat the infection.
Surgery to remove part of the bone and drain the mastoid (mastoidectomy) may be needed if antibiotic therapy is not successful. Surgical drainage of the middle ear through the eardrum (myringotomy) may be needed to treat the underlying middle ear infection.
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