Urine in diaper may darken after several hours (can become almost black)
Adult:
Progressive arthritis, especially of the spine
Darkening of the ear (from black staining of the cartilage in the ear)
Dark spots on the sclera (white of the eye) and cornea
Signs and tests:
Urinalysis is positive for reducing substance. Further urine testing shows a positive ferric chloride test.
Review Date: 4/20/2005
Reviewed By: Neal Sondheimer, M.D., PhD., Division of Genetics and Metabolism, Children's Hospital of Philadelphia, Philadelphia, PA. Review provided by VeriMed Healthcare Network.
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