Malignant hyperthermia is often noted for the first time after a patient is given anesthetic drugs during a surgical procedure. The anesthetized patient quickly develops muscle rigidity. Body temperature rapidly rises to 105 degrees F or higher. During these episodes, muscle tissue is destroyed and, eventually, kidney failure may result. Urine may turn a dark color (see rhabdomyolysis). Malignant hyperthermia is an autosomal dominant trait, meaning it requires only one parent carrying the disease for a child to inherit the condition. It may be associated with muscular diseases such as multiminicore myopathy and central core disease. The condition requires immediate treatment.
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