An exact cause of PMS has not been identified. However, it may be related to social, cultural, biological, and psychological factors. PMS can occur with apparently normal ovarian function (regular ovulatory cycles). PMS is estimated to affect up to 75% of women during their childbearing years. It occurs more often in women between their late 20s and early 40s, those with at least one child, those with a family history of a major depression disorder, or women with a past medical history of either postpartum depression or an affective mood disorder. As many as 50-60% of women with severe PMS have an underlying psychiatric disorder.
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