Reye's syndrome is most often seen in children from 4 to 12 years old, with a peak incidence at age 6. It is often associated with children who are given aspirin-containing medicines while they have either chickenpox (varicella) or the flu (influenza). The illness has a rapid onset and symptoms may vary greatly. Changes in mental status occur including delirium, combative behavior, and coma.
Typically, Reye's syndrome follows an upper respiratory infection (URI) or chickenpox by about a week. It frequently begins with vomiting, which is persistent over many hours. The vomiting is rapidly followed by irritable and combative behavior. As the condition progresses, the child may become semi-conscious or stuporous. Ultimately, seizures and coma develop, which can quickly lead to death.
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