Neonatal cystic fibrosis screening

Injury	Disease	Nutrition	Poison

Symptoms	Surgery	Test	Special Topic

Infant blood sample

Overview

Risks

Results

Neonatal cystic fibrosis screening

Alternative Names:

Cystic fibrosis screening - neonatal; Immunoreactive trypsinogen; IRT test

Normal Values:

The predicted value of a normal or negative test is an immunoreactive trypsinogen value less than 140 ng/dL.

Note: ng/dL = nanograms per deciliter

What abnormal results mean:

If your child's level of immunoreactive trypsinogen is greater than 140 ng/dL on the first screen, the test result is considered positive. If your child's level is 120 ng/dL on the second screen, the second test result is also considered positive.

Although these two test results indicate CF may exist, a sweat test with a positive result is necessary to confirm the diagnosis.

References:

Gross, SD, Boyle, CA, Botkin, JR, et al. Newborn Screening for Cystic Fibrosis:Evaluation of Benefits and Risks and Recommendations for State Newborn Screening Programs. MMWR. 2004;53(RR13);1-36.

Review Date: 5/16/2005
Reviewed By: A.D.A.M. Editorial. Previously reviewed by John Goldenring, M.D., MPH, Department of Pediatrics, Children's Hospital, San Diego, CA. Review provided by VeriMed Healthcare Network.

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