A tongue biopsy can be performed with a needle. After numbing the area, the needle is inserted into the tongue, and a small core of tongue tissue is removed. A tongue biopsy can also be performed by thinly slicing a piece of tongue tissue (incisional biopsy), or by surgical excision (excisional biopsy, usually under general anesthesia) of a lesion, growth, or area of the tongue that appears abnormal.
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