The test can detect chromosomal disorders -- such as Down's syndrome, structural defects -- such as spina bifida (open spine, where the vertebrae fail to close), anencephaly (a condition in which the brain is incomplete or missing), and many rare, inherited metabolic disorders. Later on in a pregnancy, the test may be used to identify suspected problems such as Rh incompatibility or infection. Late in the pregnancy, lung maturity can be determined using this test.
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